国际知名品牌Target Mol与Topscience开展战略合作

    2014年12月，Topscience与TargetMol正式签署为期三年的战略合作协议，作为Target Mol在大中国地区的服务机构，陶素将负责Target Mol在中国市场的产品销售、技术应用与支持等各项业务，为中国大陆及包括台湾，香港和澳门在内的大中国地区客户提供快速，便捷的服务Topscience将始终秉承“Chemistry for a better life” 之理念，一如既往地为国化学行业广大科研和生产用户提供品质卓越的产品与一流的服务！

    Target Molecule位于美国生物医药最发达的马赛诸塞州，这里有多达900家Healthcare领域的公司，从大型医院到生物技术公司，都对药物小分子的研究注以浓厚的兴趣。为了以最快的速度获得新型药物分子或进行细胞诱导的实验，研究者利用已经上市或报道的药物小分子进行老药新用或信号通路的研究。但通常这些药物小分子的收集工作是非常繁琐的，会耗费科学家们大量的时间。同时，由于分子和细胞水平的实验用量较小，又增加了对实验材料的浪费。为了解决这个问题，TargetMolecule公司推出了各种上市药物小分子库和活性抑制剂小分子库，以1mg，5mg的干粉和10mM的溶液向医药领域的客户提供灵活的产品集合，帮助生物学家和药学家得到了具有明确活性和毒性的上市药物研究的小分子，并收集了大量的抑制剂小分子以供科学家们进行细胞信号转导，细胞诱导，老药新用以及阳性对照的实验。

在未来的三年中，Target Mol将授权Topscience经营其中国市场业务，依靠Topscience强大的市场优势和Target Mol自身产品的竞争力，为中国的生物，药学和化学家们提供更加便捷和优质的活性小分子化合物。

Target Mol优势产品系列摘录如下：

1. USA Drug Collection

USA Drug Collection has already been put into the market'' including 1280 kinds of small molecular drug compounds in the America. These medicines are assigned by USP or USAN. There are different format for these drug compounds 1mg'' 5mg and DMSO 10mM dissolvent concentration. All the compounds in this library not only make bioassay experiments'' but also finish clinical effective assessment. Every compound includes product data information in detail. Such as structure'' CAS number'' molecular formula'' molecular weight'' bioactivity and commodity name. Pharmacology and toxicology reference documentation is also included.

Advantages

There are rich document references and reliable data demonstrations. Every compound is selected by medicinal and biological chemist'' has good biological activity and structural diversity.

These medicines corresponding disease and medicine toxicological document has been open in public. You can be fully supported by toxicological data and find new functions.

The average purity is above 95%. If there are no special instructions'' purity of every compound are all higher than 90%.

Applications

It is adopted by new users for old drugs'' module establishment'' drug selection experiments and so on. On the one hand'' we offer convenient research tools for known medicinal activity assessment. On the other hand'' we offer excellent research tools to cell biologist to conduct cell induce experiment.

Package condition

Dry chemical powder quality guarantee period is more than 1 year.

We suggest liquor products are used up in 6 months. Because with repeated frosted'' it is possible to appear products’ degradation.

The delivery cost is different depending on the customers’ countries.

The list price for the USA Drug Collection is as follows.

250ul 10mM concentration in DMSO solution of USA Drug Collection: 12800 USD

500ul 10mM concentration in DMSO solution of USA Drug Collection: 18602 USD

1ml  10mM concentration in DMSO solution of USA Drug Collection: 23688 USD

1mg  USA Drug Collection:12800 USD  

5mg 1280 USA Drug Collection: 37120 USD

2.Selective Drug Collection

The selective Drug Collection including 400 kinds of small molecular drug on the America'' Europe and Asia market. These medicines are certified by USP'' USAN'' INN'' BAN'' JAN and so on. All are in stock'' twelve 96 plate'' is DMSO 10mM dissolvent concentration. Different from other products on the market'' the 400 products not only make bioassay experiments'' but also finish clinical effective assessment. Every compound includes product data information in detail. Such as structure'' CAS number'' molecular formula'' molecular weight'' bioactivity and commodity name. Pharmacology and toxicology reference documentation is also included.

Advangtages

There are rich document references and reliable data demonstrations. Every compound is selected by medicinal and biological chemist'' has good biological activity and structural diversity.

These medicines corresponding disease and medicine toxicological document has been open in public. You can be fully supported by toxicological data and find new functions.

The average purity is above 95%. If there are no special instructions'' purity of every compound are all higher than 90%.

Application

It is adopted by new users for old drugs'' module establishment'' drug selection experiments and so on. On the one hand'' we offer convenient research tools for known medicinal activity assessment. On the other hand'' we offer excellent research tools to cell biologist to conduct cell induce experiment.

Package condition

We can offer 1mg to 5mg packing dry powder'' and also can provide 10mmol/L DMSO solution. Dry chemical powder quality guarantee period is more than 1 year. We suggest liquor products are used up in 6 months. Because with repeated frosted'' it is possible to appear products’ degradation.

250ul 10mM concentration in DMSO solution:  4''000 USD

500ul 10mM concentration in DMSO solution: 5''950 USD

1ml  10mM concentration in DMSO solution: 7''900 USD

1mg  Drug Collection: 4''000 USD                   

5mg  Drug Collection: 11''500USD

3．HTS Drug Collection

HTS Drug Collection has already emerged into the market'' including 2000 kinds of small molecular drug on in the North AmericanAmerica'' European and Asian market. These medicines are certified by USP''USAN'' INN'' BAN'' JAN and so on. All are in stock'' twelve 96 plate'' is withDMSO 10mM dissolventconcentration in DMSO. Different from other products on in the market'' the 2000 products have been certified not only make by bioassay experiments'' but also finish through clinical effective assessment. Every compound includes product data information in detail. Such'' such as structure'' CAS number'' molecular formula'' molecular weight'' bioactivity and commodity name. Pharmacology and toxicology reference documentation is also included.

Advantages

There are rich abundent abundant document references and reliable data demonstrations. Selected by medicinal and biological chemist'' eEvery compound is selected by medicinal and biological chemist'' has good biological activity and structural diversity.

Disease targeted by tThese medicines corresponding disease and medicine toxicological document has have been open in public. You can be fully supported by toxicological data and find new functions.

The average purity is above 95%. If there are no special instructionsnotice'' purity of every compound are all higher than 90%.

 Applications

It is adopted by in new users research/disease for old drugs'' module establishment'' drug selection experiments and so on. On the one hand'' we offer convenient research tools for known medicinal activity assessment. On the other hand'' we offer excellent research tools to for cell biologist to conduct cell induce experiment.

There are two examples'' one is MItifus'' which is was used for curing mammary cancer and '' now it treats leishmanisis (leishmaniasis is zoonosis caused by leishmansia) It is transmitted by articulate and arthropods. This disease is happened in more than 100 countries. Every year the number of new cases is more than 40 million'' causing 5 million people death. Another the other one is Viagra. This disease is used for curing new colic'' while clinical effect is less than expected'' but in America in Pfizer Company’s at Auster Building accidently found that indViagra made some patients with heart disease take Viagra because of heart disease''causing Penis smooth muscle relaxationbecauserelaxation because of side effect. Because ofWith blowing blood increasing'' it improves improved erectile function. Then through repeated experiment'' it is was certified that Viagra  iswas definitely effective for erectile function.

 Package condition

We can offer not only 1mg to 5mg packing dry powder'' and but also can provide 10mmol/L DMSO solution. The war renty for dDry chemical powder quality guarantee period is more than 1 year. We suggest that liquor products are should be used up in within 6 months. Because withWith repeated frosted'' it is possible to appear products’ degradation.

The list price for the HTS Drug Collection is as follows.

250ul 10mM concentration in DMSO solution of USA Drug Collection:  199''700 USD

500ul 10mM concentration in DMSO solution of USA Drug Collection:  299''500 USD

1ml  10mM concentration in DMSO solution of USA Drug Collection:  399''300 USD

1mg  USA Drug Collection:  199''700 USD   

5mg 1280 USA Drug Collection: 599''950 USD

4. Europe&Asia Durg Collection

Our drug compounds Collection including 480 kinds of small molecular drug marketed in Europe and/or Asia. These medicines are certified by INN / BAN / JAN and so on. Different from other products on the market'' the 480 products not only make bioassay experiments'' but also finish clinical effective assessment. Every compound includes product data information in detail. Such as structure'' CAS number'' molecular formula'' molecular weight'' bioactivity and commodity name. Pharmacology and toxicology reference documentation is also included.

Advantages

There are abundantdocument references and reliable data demonstrations. Every compound selected by medicinal and biological chemisthas good biological activity and structuraldiversity.

These medicines corresponding disease and medicine toxicological document has been open in public. You can be fully supported by toxicological data and find new functions.

The average purity is above 95%. If there are no special instructions'' purity of every compound are all higher than 90%.

 Applications

It is adopted by new users for old drugs'' module establishment'' drug selection experiments and so on. On the one hand'' we offer convenient research tools for known medicinal activity assessment. On the other hand'' we offer excellent research tools to for cell biologist to conduct cell induce experiment.

 Package condition

We can offer not only 1mg to 5mg packing dry powder'' and butalso can provide 10mmol/L DMSO solution. Dry chemical powder qualityThe guarantee warrantyperiod for dry chemical powderis more than 1 year. We suggest liquor products are used up in 6 months. Because withWith repeated frosted'' it is possible to appear products’ degradation.

The list price for the Europe &Asia Drug Collection is as follows.

250ul 10mM concentration in DMSO solution: 4''800 USD

500ul 10mM concentration in DMSO solution: 7''200 USD

1ml  10mM concentration in DMSO solution:  9''500 USD

1mg  USA Drug Collection: 4''800 USD   

5mg 1280 USA Drug Collection: 13''900 USD

5. Natural Compounds Library

Natural compounds are famous for the novelty of the structures. There are 800 natural products in our Natural compoundslibrary.These natural product screening compounds was refinedfrom plants and microorganisms. Most compounds have purity above 90% on average. The structures and stereochemistry are confirmed by various physicochemical analytical methods'' including NMR'' mass spectroscopy and in some cases X-ray analysis. They are supplied in 96-well format'' with other formats available upon request.We welcome cherry-picking of individual natural products from our Natural compounds library.

The list price for the Collection is as follows.

250ul 10mM concentration in DMSO solution: 11''500 USD

500ul 10mM concentration in DMSO solution:  17''500 USD

1ml  10mM concentration in DMSO solution: 22''000 USD

1mg   Collection:  11''500 USD   

5mgCollection:  33''350 USD

6. Human Endogenous Compounds

This library includes formed molecules or intermediatemolecules in the process of the human body existed metabolic process. For example'' related with the human peripheral nervous system has Ach''NA'' histamine and so on. The research based Endogenous biological active substance is a new hot center in drug development. We can provide more than 200 human endogenous compounds'' including Human endogenous compoundsEC_，organism'' Pathways'' Formula'' Donor'' Acceptor'' LogP'' MW related data. 1mg to 5mg can both be provided.

There are several endogenous active substances in anti-aging effect listed below:

1. Hyaluronic acid

Anti-Aging principle is transparent human natural moisturizing ingredients'' keep  moist and promote other activity ingredient absorb'' offer good environment for the dermal collagen and elastic fiber synthesis and relieve aging wrinkles.

2. SOD

SOD is abbreviation of Super Oxide Dimutesef. Its Chinese name is Super Oxide Dimutesef. It is a biological antioxidant enzyme in organisms. It widely located in different kinds of organism such as animals'' plants and microform and so on.SOD has special bioactivity. It is primary substances in eliminating free radical. Level in organism means direct index of the aging and death. Now it can be proved that oxygen free radicals are more than 60.It can block oxygen free radicals harmful to cell'' repair damaged cell in time''andthe complex causes of free radicals causes harmful to cells. Because of modern pressure'' environment pollution all kinds of radiation and excessive movement will cause a large amount of oxygen free radical. Therefore''SOD plays an important role in Biological antioxidant mechanism.

The list price for the USA Drug Collection is as follows.

250ul 10mM concentration in DMSO solution: 9''700 USD

500ul 10mM concentration in DMSO solution: 14''550 USD

1ml  10mM concentration in DMSO solution: 18''788 USD

1mg   Collection: 9''700 USD  

5mgCollection: 27''120 USD

7. Metabolism & Impurity Library

Metabolism and impurity library is selected from 1 million active product libraries'' 200 products in all'' high cost performance'' good diversity; ability of repeated supply is strong. Purity of most compoundsis higher than 95%''suitable for related customers demand for drug screening research. All products are packed in two dimension code Matrix-379096 plates. Standard package is 1mg dry powder ofeach product'' which is convenient for storage and usage. If you need solution or other specifications'' we can also provide.

 Why we recommend you this library?

With development of research'' Scientists has discovered many definite bioactivities in Drug / metabolite isomers. Forexample''Dextropropoxyphene 2 dextroisomerkill the pain''levoisomerrelief one’s cough. D sotalolbelongs to beta blocker. Because these compounds have rich pharmacology elevation data in research'' it can help scientists save a large number of pharmacokinetics experiments. Elevate its other potential activity directly. Put these experimental tools for new uses of old drugs to research and innovate.

The list price for the Metabolism and impurity library Collection is as follows.

250ul 10mM concentration in DMSO solution: 5''900 USD

500ul 10mM concentration in DMSO solution:  8''673 USD

1ml  10mM concentration in DMSO solution:  11''500 USD

1mg  Drug Collection: 5''900 USD   

5mg  Drug Collection:   17''110 USD