RECEPTORS UCC003

重组人CD40-ECD

CAT编号UCC003

批号A0031

0.1 mg /小瓶

CD40是TNF受体超家族的成员。已经发现这种受体在介导

多种免疫和炎症反应，包括T细胞依赖性免疫球蛋白类别

转换，记忆B细胞发育和生发中心形成。 AT钩转录因子AKNA

据报道可以协调调节该受体及其配体的表达，这可能很重要

用于同型细胞相互作用。衔接蛋白TNFR2与该受体相互作用，并充当

信号转导。发现该受体及其配体的相互作用是必要的

β-淀粉样蛋白诱导的小胶质细胞活化，因此被认为是阿尔茨海默病的早期事件

疾病发病机理。该基因的两个选择性剪接的转录变体，编码不同的同工型

已经汇报过。

参考序列：

备用名称：

基因编号：

NM_001250

NP_001241

瑞士保护套P25942

肿瘤坏死因子受体超家族成员5亚型1

TNF受体超家族成员5

CD40抗原

CD40L受体

CD40 II型同工型

神经生长因子受体相关的B淋巴细胞活化分子

ELL相关分子

B细胞表面抗原CD40

肿瘤坏死因子受体超家族成员5

B细胞表面抗原CD40

958

克隆了包含细胞外结构域ECD的人CD40的21-193位残基，蛋白

在HEK293细胞中过表达，并纯化至同质。计算分子量

重组人CD40-ECD为20.5 kDa，它包含一个C端六组氨酸标签。每个小瓶包含100个

μg CD40-ECD浓度为3.4 mg / ml。

储存稳定性

重组CD40--ECD应储存在-80℃（稳定至少1年）。该蛋白质储存在PBS中。后

解冻后，应将其以适当的小等分试样保存在-20?C或-80?C（稳定至少2个月）。

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版本10/2018

产品描述

Recombinant human CD40-ECD

CAT No. UCC003

LOT No. A0031

0.1 mg/vial

CD40 is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a

broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class

switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA

is reported to coordinately regulate the expression of this receptor and its ligand, which may be important

for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of

the signal transduction. The interaction of this receptor and its ligand is found to be necessary

for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer

disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms

have been reported.

Reference sequences:

Alternative names:

Gene ID:

NM_001250

NP_001241

Swiss-prot P25942

tumor necrosis factor receptor superfamily member 5 isoform 1

TNF receptor superfamily member 5

CD40 antigen

CD40L receptor

CD40 type II isoform

nerve growth factor receptor-related B-lymphocyte activation molecule c B

ell-associated molecule

B cell surface antigen CD40

tumor necrosis factor receptor superfamily member 5

B-c ell surfac e antigen CD40

958

Residues 21-193 of human CD40, containing the extracellular domain - ECD -, were cloned, the protein was

over-expressed in HEK293 cells and was purified to homogeneity. The calculated molecular weight of

recombinant human CD40-ECD is 20.5 kDa and it contains an C-terminal hexahistidine tag. Each vial contains 100

μg CD40-ECD at a concentration of 3.4 mg/ml.

Storage and stability

Recombinant CD40--ECD should be stored at - 80 ?C (stable for at least 1 year). The protein is stored in PBS. After

thawing it should be stored in appropriate small aliquots at - 20 ?C or - 80 ?C (stable for at least 2 months).

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Version 10/2018

Product Description