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bpsbioscience，27762-2，2-Methoxyestradiol (2-MeOE2)

产品报价：询价

更新时间：2019/2/19 16:38:02

产地：美国

品牌：bpsbioscience

型号：27762-2

厂商性质：生产型,贸易型,服务型,

公司名称：世联博研（北京）科技有限公司

产品关键词： 2-MeOE2 2-Methoxyestradiol bpsbioscience Betulinic acid

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MW: 302.4 Da

CAS Registry #: 362-07-2

Formula: C₁₉H₂₆O₃

Background:

2-Methoxyestradiol is currently in clinical trials as a therapeutic against breast and ovarian cancer. Preclinical models also suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis. Several studies have been conducted showing 2ME2 is a microtubule-inhibitor and effective against prostate cancer in rodents

Description:

2-Methoxyestradiol (2-MeOE2), an endogenous metabolite of 17β-estradiol (E2), is an inhibitor of microtubule assembly that inhibits the polymerization of tubulin and interferes with mitotic spindle dynamics leading to the blockage of mitosis of human cancer cells which lack estrogen receptors in metaphase. 2-MeOE2 is also an inhibitor of tumor growth and angiogenesis. Study results have shown that 2-MeOE2 induces mammalian cell transformation and genotoxicity in Syrian hamster embryo (SHE) fibroblasts through concentration-dependent inhibition of cell growth. Moreover, 2-MeOE2 has demonstrated anti-proliferative activity against estrogen-responsive breast cancer cell line MCF-7 and subsequent inhibition of the growth of tumors subcutaneously inoculated in mice.

Synonym(s):

2-Methoxyestradiol; 2-MeOE2; 2-methoxy Estradiol

Purity:

98% purity by HPLC

Solubility:

Soluble in DMSO “~20 mg/ml

Storage / Stability:

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Reference(s):

1. Tsutsui, T., et al. Carcinogensis 2000; 21(4): 735-740.
2. Attalla, H., et al. Biochem. Biophys. Res. Commun. 1996; 228: 467-473.

Scientific Category:

Apoptosis Inducer

Product Type:

Activator/Inducer

Catalog#	Size	Product Name
27762-2	100 mg	2-Methoxyestradiol (2-MeOE2)
27762-3	300 mg	2-Methoxyestradiol (2-MeOE2)
27762-1	50 mg	2-Methoxyestradiol (2-MeOE2)
27315	5 mg	Ac-DEVD-CMK
27733-1	25 mg	Apoptosis Activator 2
27733-2	50 mg	Apoptosis Activator 2
27733-3	100 mg	Apoptosis Activator 2
27734-3	100 mg	Apoptosis Inhibitor
27734-1	10 mg	Apoptosis Inhibitor
27734-2	25 mg	Apoptosis Inhibitor
27607-2	50 mg	BAM7
27607-1	10 mg	BAM7
27738-2	10 mg	Bendamustine HCl
27738-1	5 mg	Bendamustine HCl
27739-3	500 mg	Betulinic acid
27739-1	100 mg	Betulinic acid
27739-2	200 mg	Betulinic acid
27740-1	25 mg	BIBR 1532
27611-3	25 mg	Boc-D-FMK
27611-1	5 mg	Boc-D-FMK
27611-2	10 mg	Boc-D-FMK
27741-1	5 mg	Caspase-3/7 Inhibitor I
27741-2	10 mg	Caspase-3/7 Inhibitor I
27741-3	25 mg	Caspase-3/7 Inhibitor I
27321	10 mg	CAY10625

世联博研（北京）科技有限公司

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bpsbioscience，27762-2，2-Methoxyestradiol (2-MeOE2)

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