大鼠小鼠睡眠剥夺系统 动物睡眠剥夺 SLEEP DEPRIVATION SYSTEMS

Pinnacle’s AUTOMATED SLEEP DEPRIVATION SYSTEM offers a unique solution for sleep deprivation and sleep fragmentation studies. It provides user controls for sleep depriving mice and rats without direct human intervention while minimizing exercise. The system is sold as either a STAND ALONE SYSTEM or a FEEDBACK SYSTEM in which real-time EEG/EMG activity is used to determine the sleep/wake state.

PINNACLE’S SLEEP DEPRIVATION SYSTEM is designed to gently restrict sleep without unnecessary exercise in rodents. This is achieved by a rotating bar placed a short distance above the cage floor, lightly nudging the animal from sleep and encouraging low levels of activity until the animal maintains wakefulness on its own. The speed, direction, and duration of bar rotation are fully customizable.

产品特点
? Simulates gentle handling
? Limits unnecessary exercise
? Minimizes resources compared to manual deprivation
? Prevents sleep acclimation and habituation
? Accommodates water, food, and bedding
? Provides flexible scheduling controls
? Saves schedules for future use
? Integrates with synchronized video system

EFFECTIVENESS OF SLEEP DEPRIVATION IN MICE

The chart to the right shows a comparison of baseline sleep (purple bars) with a 24-hour sleep deprivation period (gold bars). Six mice (male, C57BL/6J) were maintained on a 12-hour lights-on (horizontal tan)/ 12-hour lights-off (horizontal black) schedule. EEG and EMG activity were recorded for 24 hours (baseline). During the following 24 hours, each animal was sleep deprived by programming the system to rotate the bar within ten seconds of the mouse entering a sleep-like state, as determined by active EEG feedback. Vertical bars represent sleep time in 2-hour bins.