CLINIcell

The CLINICELL® is a compact cell culture cassette , stackable with a large surface of cultivation. Several cassettes can be interconnected, or with another medical device, for even more surface culture in a closed and secure environment.

The CLINICELL® has the necessary key characteristics for a modern culture, repeatable and efficient. It is made by laboratories MABIO International according to the GMP recommandations and has the CE marking according to Directive CE/42/93 for medical devices class IIa.

The CLINICELL® is a sterile, robust and fully closed, ensuring thus a high level of protection of both the culture and the manipulator in a completely sterile environment.

The CLINICELL® is manufactured from a biologically, chemically and immunologically inert and biocompatible materials. The CLINICELL® has a rigid frame which makes its handling simple and easier while ensuring the culture and manipulation safety.

The CLINICELL® is available in two sizes: 25 cm2 and 250 cm2, it has two culture surfaces :

- Completely flat for an homogeneous culture,

- Completely transparent for better observation and simple monitoring of culture growth,

- Gas Permeable for optimal gas exchanges,

- Plasma treated (a mixture of inert gases) to promote cells adhesion.

The CLINICELL®, depending on your setup, has a connectivity based on the standard Luer Lock connexions used in all research areas and clinical applications. Thus the change of environment, the addition of elements (nutrients, vitamins and so on. ...) during the culture is very simple without any risk of contamination or mishandling.

We work permanently in the CLINICELL® so that all conditions are met to obtain the best performance of culture and that your cells grow in a healthy, secure, with no stress or pollution environnment.

CLINIcell may be used as single device for the main operations of the cell culture laboratory :

- Culture of cells or tissues
- Transport
- Freezing / thawing

Thus, many tedious manipulations are simplified and secured. Moreover, the biological, technical and regulatory qualities of CLINICELL ensure both quality and safety of the culture, so that you will adopt the CLINICELL from your first test!

Finally, cassettes CLINICELL are economical to use compared to culture flasks :
- Less handling,
- Less space in the incubator,
- Less space in freezer
- Less consumption of media.

Do not hesitate to describe your protocols, we will help you to simplify them.
Many application examples exist. Call us, we will find one that suits to your needs.
 

CELL CULTURE

The CLINICELL is the ideal tool for a modern and healthy culture.
Its features makes it an ideal tool offering the highest security for the culture, the handler and the patient.

With its design and its multiple possibilities of connection it can be the basis or easily been integrate into a closed culture system protocol.

Of course, CLINICELL may be coated with your usual matrix (collagen, fibronectin ....).
Use the CLINICELL as a Petri dish or a flask, you will quickly discover the benefits of its use

Cell types most often grown in the CLINICELL
- Embryonic Stem Cells
- Stem cells derived from cord blood
- Stem cells from bone marrow
- Stem cells derived from adipose tissue
- Mesenchymal stromal cells
- Hematopoietic stem cells
- Adipocytes
- Endothelial cells
- Epithelial cells
- Keratinocytes
- Chondrocytes
- Smooth muscle cells
- Neuronal cells
- Dendritic cells
- NK cells
- Lymphocytes
 

CELL TRANSPORT

The CLINICELL can carry safely your fresh or frozen cells. Simply insert your cassette culture in a sterile bag, pack it in a suitable container. And that's all.

Very robust, the membranes of the CLINICELL are waterproof while allowing gas exchange between the culture and the outside atmosphere. It also allows a substantial economy in medium (10 ml vs 50 ml or 70 ml in a 25 cm2 flask).

It is possible with the CLINICELL to ship samples during cell growth or after freezing. On arrival, just renew culture medium and put the cassette in the incubator. Cell proliferation restarts very easily.

FREEZING CELLS

The CLINICELL easily resists to extreme temperatures up to -156 ° Celsius. It also supports rapid thawing. Simply remove the cassette from the freezer, plunge it in a water bath at 37 °C. . After thawing (few minutes), change the freezing media for culture media and place the CLINICELL in the incubator. The proliferation naturally restart.
The freezing of the cells directly into the cassette CLINICELL avoids the manipulations and the cellular stress related to cells' trypsinization and centrifugation .

Freezing :
- No enzymatic detachment,
- No centrifugation,
- Freezing during proliferation phase.
 

10 raisons to choose Clinicell

The reasons which show that the CLINIcell ® is currently the most suitable device for a modern and healty cell culture.

1 - closed and secure system : for both culture for handler,

2 - Surface culture of 25cm² and 250cm² perfectly flat : for an homogeneous distribution of cells,

3 - Gas Permeable for good cell growth,

4 - Perfectly transparent surface : Allows monitoring of culture under the microscope,

5 - Small medium volume providing substantial economy of media and reagents,

6 - Compact and stackable ensuring ease of use and saves space in the incubator,

7 - Biocompatible and plasma treated cell culture surfaces for better adhesion of the cells,

8 - Fully and easily perfusable,

9 - Allows easy connectivity to various devices on the market thanks to the standard Luer connexions,

10 - CE Marked & sterile for better safety in use and a guarantee for therapeutic applications.

 Specifications

Description :

Completely closed and secure cell culture system.

Target :

Assure a sterile, secure and controlled cell culture environment.

Some applications :

- Expansion of hematopoietic progenitors.

- Production of dendritic cells from adherent monocytes and CD34 + cells.

- Selection and expansion of mesenchymal cells.

- Culture and antibody production.

- Culture of cell lines, etc...

Dimensions :

CLINIcell® 25 : 72 mm x 97 mm x 12 mm

CLINIcell® 250 : 265 mm x 182 mm x 16 mm.

Surface de Culture :

CLINIcell® 25 : 25 cm² per face

CLINIcell® 250 : 250 cm² per face

Cell culture surfaces are perfectly flat to ensure a homogeneous distribution of cells. The 2 surfaces are optionally treated plasma to promote cells adhesion.

Volume :

CLINIcell® 25 : 11 ml

CLINIcell® 250 : 120 to 160 ml.

Elements :

Polycarbonate rigid frames, polycarbonate gas permeable film. The rigid structure of CLINIcell ® allows cassettes stacking , easier handling and increased security.

Taux de Transfert gazeux en ml/mil/100 in²/24 hr/atm :

- Air 85 - Nitrogen 50 - Oxygene 300 - Carbon dioxid 1.075

Connexions :

By syringe or directly by connecting it to a luer fitting device. Any type of standard Luer connection (valve, bag, filters etc ...)

Options de Perfusion :

The CLINIcell ® can be connected in parallel or in series to a peristaltic pump and to any other system such as culture or media bags.

Observability :

The excellent optical properties of the polycarbonate film allow a perfect observability of the culture under microscope and monitoring of the cell growth.

Packaging :

Double sterile packaging for single use.

Storage :

A dry, dark and at room temperature.

User Manuals :

Available in downloadable PDF format : the manuals are in French or English..

Certification :

CE marking number : 2111774CE01 by KEMA. Available in downloadable PDF format in the Quality section.

CLINIcell benefits

The benefits to use the CLINICELL culture cassettes are demonstrated daily by our customers.

Overall, CLINICELL combines the advantages of flasks and culture bags in a closed and secured device for a perfectly controlled environment.
Thus you will obtain :
Optimal growth, survival, functionnal rates,
Exact reproducibility of experiments consistent with the results of one test to another,
A very good observability under microscope,
Multiple connection options (luer lock)
A good gas permeability due to surface treatments,
Gain of room on the shelf and in the incubator
Optimum culture area,
Completely sterile environment,