S1019 CI-1033(Canertinib)

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Synonyms:
CANERTINIB，PD-183805 

Biological Activity:
CI-1033 effectively inhibits the growth of esophageal squamous cell carcinoma which co-expresses both EGFR and HER2 with the inhibition of phosphorylation of both MAPK and AKT. CI-1033 was highly potent against EGFR (IC50 0.8 nM), HER-2 (IC50 19 nM) and ErbB-4 (IC50 7 nM).

Related Compounds:
BMS-599626 :An oral pan-HER inhibitor
 
Technical Data:
M.Wt:  485.94
Formula:  C24H25ClFN5O3
Solubility:  DMSO
Purity:  99%
Storage:  -20C 2 years
CAS No:  267243-28-
 

北京乐博生物科技有限公司代理供应美国Selleck chem公司全线产品。全国1周内到货