S1494 LY2228820 (Synonyms LY-2228820) 现货

北京乐博生物科技有限公司代理供应美国Selleck chem公司全线产品。

该产品另有其他规格及报价，欢迎来电垂询。

Technical Data:
M.Wt: 612.74
Formula: C₂₄H₂₉FN₆.2CH₄O₃S
Solubility: Unknown
Purity: >99%
Storage: -20℃ 2 years
CAS No.: 862507-23-1
 

Biological Activity:
 

LY2228820 is a novel and potent p38MAPK inhibitor: in vitro kinase enzyme activity showed that the IC50 for p38αMAPK and p38βMAPK were 7 nM and 3 nM, respectively, while that for p38δMAPK, p38γMAPK and a panel of 172 additional kinases was more than 20 µM. Phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, was significantly inhibited by LY in both MM cell lines and LT-BMSCs. ^[1]