产品报价：询价
更新时间：2012/7/18 17:15:14
产地：北京
品牌：selleck
型号：S2192
厂商性质： 生产型,贸易型,服务型,
公司名称： 北京乐博生物科技有限公司
刘小姐 : (13621283223) (4006130504)
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北京乐博生物科技有限公司代理供应美国Selleck chem公司全线产品。
AZD8931 is a novel potent reversible small molecule epidermal growth factor receptor, ERBB2 (HER2) and ERBB3 inhibitor with an IC50 of 4, 3, 4 nM, respectively. In proliferation assays, AZD8931 was significantly more potent than gefitinib or lapatinib in specific squamous cell carcinoma of the head and neck and non-small cell lung carcinoma cell lines. In vivo, AZD8931 inhibited xenograft growth in a range of models while significantly affecting EGFR, erbB2, and erbB3 phosphorylation and downstream signaling pathways, apoptosis, and proliferation. It has a unique pharmacologic profile providing equipotent inhibition of EGFR, erbB2, and erbB3 signaling and showing greater antitumor activity than agents with a narrower spectrum of erbB receptor inhibition in specific preclinical models. [1][2][3]
