Ispinesib mesilate(SB-715992)现货

Technical Data:
M.Wt: 517.06
Formula: C30H33ClN4O2
Solubility: Unknown
Purity: >99%
Storage: at -20℃ 2 years
CAS No.: 336113-53-2

Biological Activity of Ispinesib mesilate(SB-715992):
Ispinesib mesilate(SB-715992) is an agent which inhibits the mitotic kinesin KSP (Eg5) with a Ki of 0.6 nM and has cytotoxic activity at less than 10 nM in a spectrum of tumor cell lines. [1]
Ispinesib mesilate is a potent inhibitor of kinesin spindle protein, a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis. Clinical studies of Ispinesib mesilate have shown a 9% response rate in patients with locally advanced or metastatic breast cancer and a favorable safety profile without significant neurotoxicities, gastrointestinal toxicities, or hair loss. [2]
In vivo, Ispinesib mesilate enhanced the antitumor activity of trastuzumab, lapatinib, doxorubicin, and capecitabine and exhibited activity comparable with paclitaxel and ixabepilone. [2]

北京乐博生物科技有限公司代理供应美国Selleck chem公司全线产品。