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MQR2.3401	anti-WARS
MQR2.3401	anti-WARS
  • MQR2.3401	anti-WARS

MQR2.3401 anti-WARS

产品报价:询价

更新时间:2023/4/3 18:11:18

地:美国

牌:ImmunoPrecise

号:MQR2.3401

厂商性质: 生产型,

公司名称: 世联博研(北京)科技有限公司

产品关键词: human tryptophanyl-tRNA synthe   anti-WARS   MQR2.3401   MQR2.3401 anti-WARS   Human IgG1  

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品名


抗色氨酸tRNA单克隆抗体


合成酶免疫球蛋白


货号。


MQR 2.3401号


批号。


18296年


数量


100微克


版本:2019年9月11日


预期用途


本产品仅供研究使用。不用于诊断或


治疗程序。


该产品经测试可用于酶联免疫吸附试验


(ELISA)和免疫沉淀(IP)。


提供试剂


抗体以PBS形式提供。


同型


人IgG1-κ


免疫原


色氨酸tRNA合成酶。域名:P2-Q471/471。


特异性


特异性已在ELISA(图1)和IP-MS中测试。


纯度


纯化蛋白A。


免责声明


该抗体仅供研发使用。不用于诊断或


治疗程序。


注意事项


一。对于专业用户。


2。与任何来自生物源的产品一样


应使用处理程序。


三。该产品可用于不同的技术和


结合不同的样品类型和材料,


因此,每个实验室应验证


应用测试系统。


抗体的制备


使用提供的抗体。


储存/稳定性


储存于-20°C。首次使用后,储存于4°C。避免重复冻融循环。


应用指南


酶联免疫吸附试验:1:200–1:1000


IP:2微克/毫升


其他用途:由于用途不同,最佳工作稀释度


应在适当的分析中测定产品的含量。


除非实际测试系统的稳定性已经确定,否则


建议在使用前立即稀释产品。


关联


亚型1、亚型2和T1 TrpRS具有氨基酰化活性,而


T2-TrpRS缺少它。亚型2,T1-TrpRS和T2-TrpRS具有血管抑制作用


活性而亚型1缺乏。T2-TrpRS抑制内皮细胞的流体剪切应力激活反应。调节ERK、Akt和eNOS


与血管生成、细胞骨架相关的激活途径


重组和剪切应力反应基因表达。1


图1:用酶联免疫吸附试验测定抗战争特异性(MQR2.3401)。抗体储备0.7 mg/ml)


在含有0.05%吐温-20和1%牛血清白蛋白的PBS中稀释后,在人色氨酸tRNA上进行试验


合成酶(蓝色)和非靶蛋白(红色)



Product Name

Monoclonal Human anti-tryptophanyl-tRNA

synthetase Immunoglobulin

CAT No.

MQR 2.3401

LOT No.

18296

Quantity

100 μg

Edition: September 11, 2019

Intended use

This product is for research use only. NOT for use in diagnostic or

therapeutic procedures.

This product is tested for use in enzyme-linked immunosorbent assay

(ELISA) and immunoprecipitation (IP).

Reagent provided

The antibody is supplied in PBS.

Isotype

Human IgG1κ

Immunogen

Tryptophanyl-tRNA synthetase. Domain: P2-Q471 of 471.

Specificity

Specificity has been tested in ELISA (figure 1) and IP-MS.

Purity

Protein A purified.

Disclaimer

The antibody is for R&D use only. NOT for use in diagnostic or

therapeutic procedures.

Precautions

1. For professional users.

2. As with any product derived from biological sources, proper

handling procedures should be used.

3. The product may be used in different techniques and in

combination with different sample types and materials,

therefore each individual laboratory should validate the

applied test system.

Preparation of the antibody

Use antibody as supplied.

Storage/Stability

Store at -20°C. After first time use, store at 4°C. Avoid repeated freezethaw cycles.

Application guidelines

ELISA: 1:200 – 1:1000

IP: 2 μg/ml

Other applications: since applications vary, optimum working dilution

of the product should be determined in the appropriate assay.

Unless the stability in the actual test system has been established, it is

recommended to dilute the product immediately before use.

Relevance

Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while

T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic

activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stressactivated responses of endothelial cells. Regulates ERK, Akt, and eNOS

activation pathways that are associated with angiogenesis, cytoskeletal

reorganization and shear stress-responsive gene expression.1

Figure 1: Specificity of anti-WARS (MQR2.3401), determined by ELISA. Antibody stock 0.7 mg/ml)

diluted in PBS containing 0.05% tween-20 and 1% BSA was tested on human Tryptophanyl-tRNA

synthetase (in blue) and non-target protein (in red)..