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10127060001-β-Glucuronidase/Arylsulfatase
10127060001-β-Glucuronidase/Arylsulfatase
  • 10127060001-β-Glucuronidase/Arylsulfatase

10127060001-β-Glucuronidase/Arylsulfatase

产品报价:771元

更新时间:2018/9/3 10:40:59

地:瑞士

牌:罗氏

号:10127060001

厂商性质: 生产型,

公司名称: 上海嵘崴达实业有限公司

产品关键词: β-Glucuronidase/Arylsulfatase   芳基硫酸酯酶   罗氏试剂10127060001   10127060001   β-葡萄糖醛酸酶  

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Features and Benefits

 Deconjugate and detect both glucuronides and sulfate esters.
 Quickly screen for steroids, benzodiazepines, cannabinoids, opioids, and other drugs.

Principle

Glucuronidation is one of the basic principles of metabolism. Most substances presented to the human body undergo metabolic processing that includes conjugation with glucuronic acid by UDP-glucuronosyltransferases (UGTs). This enzyme catalyzes the transfer of a glucuronyl group to many biological and pharmacologically active endogenous and exogenous molecules. Glucuronide is in general more soluble, less toxic, and more easily excreted by the human body compared to the original molecule.
In addition, sulfation of the drug or chemical substance by sulfotransferases in the human body may occur.  

Working concentration: In many applications the product can be diluted with water immediately before use or employed undiluted.
Note: The present β-glucuronidase/arylsulfa

tase preparation is very concentrated and must be diluted for some applications. Moreover, in the preparation of protoplasts, the precise concentration to use for a given strain of yeast must be found empirically.
Storage conditions (working solution): Note: Aliquot portions of the diluted preparation may be stored at -15 to -25 °C; they should not be thawed and refrozen more than a time or two, and storage at the lower temperature does not lengthen their life beyond that of the product kept at 2 to 8 °C.

pecificity

 β-Glucuronidase/Arylsulfatase shows a broad specificity for many kinds of β-glucuronides and sulfate esters.