LY2857785 is a potent and selective CDK9 inhibitor; significantly
reduces RNAP II CTD phosphorylation and dramatically decreases MCL1
protein levels to result in apoptosis in a variety of leukemia and solid
tumor cell lines.
上海兴默生物现货供应 LY2857785，CAS 1619903-54-6
Target: CDK9 inhibitor
inhibits the growth of a broad panel of cancer cell lines, and is particularly efficacious in leukemia cells, including orthotopic leukemia preclinical models as well as in ex vivo acute myeloid leukemia and chronic lymphocytic leukemia patient tumor samples.