Rabbit Anti-beta-Actin (Loading Control) antibody (bs-0061R)
产品报价:828元
更新时间:2017/7/4 13:38:33
产地:北京
品牌:bioss
型号:bs-0061R
厂商性质: 生产型,
公司名称: 北京博奥森生物技术有限公司
韩进良 : (13691175203) (010-56495215)
(联系我时,请说明是在来宝网上看到的,谢谢!)产品报价:828元
更新时间:2017/7/4 13:38:33
产地:北京
品牌:bioss
型号:bs-0061R
厂商性质: 生产型,
公司名称: 北京博奥森生物技术有限公司
韩进良 : (13691175203) (010-56495215)
(联系我时,请说明是在来宝网上看到的,谢谢!)background:
Loading Control
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008].
Function:
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subunit:
Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Found in a complex with XPO6, Ran, ACTB and PFN1. Component of the MLL5-L complex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with XPO6 and EMD. Interacts with ERBB2.
Subcellular Location:
Cytoplasm. cytoskeleton.
Tissue Specificity:
Ubiquitously expressed in all eukaryotic cells.
Post-translational modifications:
ISGylated.
Oxidation of Met-44 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or the (R)-S-oxide is produced.
DISEASE:
Defects in ACTA1 are the cause of nemaline myopathy type 3 (NEM3) [MIM:161800]. A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination. The phenotype at histological level is variable. Some patients present areas devoid of oxidative activity containg (cores) within myofibers. Core lesions are unstructured and poorly circumscribed.
Defects in ACTA1 are a cause of myopathy congenital with excess of thin myofilaments (MPCETM) [MIM:161800]. A congenital muscular disorder characterized at histological level by areas of sarcoplasm devoid of normal myofibrils and mitochondria, and replaced with dense masses of thin filaments. Central cores, rods, ragged red fibers, and necrosis are absent.
Similarity:
Belongs to the actin family.
SWISS:
P60709
Gene ID:
60
Database links:
Entrez Gene: 396526 Chicken
Entrez Gene: 60 Human
Entrez Gene: 11461 Mouse
Entrez Gene: 100009272 Rabbit
Entrez Gene: 81822 Rat
Omim: 102630 Human
SwissProt: P60706 Chicken
SwissProt: P60712 Cow
SwissProt: P60708 Horse
SwissProt: P60709 Human
SwissProt: P60710 Mouse
SwissProt: P29751 Rabbit
SwissProt: P60711 Rat
SwissProt: P60713 Sheep
Unigene: 520640 Human
Unigene: 708120 Human
Unigene: 727576 Human
Unigene: 328431 Mouse
Unigene: 391967 Mouse
Unigene: 94978 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
内参抗体
β-Actin是横纹肌肌纤维中的一种主要蛋白质成分,也是肌肉细丝及细胞骨架微丝的主要成分。具有收缩功能,分布广泛,具有高度保守性,在细胞中的表达相对稳定,因此常被用作校正系统的内参。β-Actin分子量为42 kDa,
此抗体主要用于标记平滑肌及其来源的肿瘤。
我公司开发的β-Actin抗体已被国内外广大科研工作者使用,被称谓:质量信得过产品.