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现在位置首页>实验室原料试剂耗材>蛋白质,多肽>总蛋白>现货Recombinant Human BMP-7
现货Recombinant Human BMP-7
现货Recombinant Human BMP-7
  • 现货Recombinant Human BMP-7

现货Recombinant Human BMP-7

产品报价:1500元

更新时间:2015/1/7 9:37:18

地:上海

牌:PeproTech

号:120-03

厂商性质: 生产型,贸易型,服务型,

公司名称: 上海生基生物科技有限公司

产品关键词:

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数量:大量
规格:10ug
Description:
TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. BMP-7, also known as osteogenic protein-1 or OP-1, is a potent bone inducing agent, which in the presence of appropriate osteoconductive carrier (e.g. collagen sponge or synthetic hydroxyapatite) can be used in the treatment of bone defects. A bone-graft substitute, called OP-1TM implant, made of recombinant human BMP-7 associated with bovine bone-derived collagen, has recently been approved by the FDA as a device for treating critical-size bone fractures. The potential use of BMP-7 in dental reconstructive surgeries is currently under investigation. Recombinant human BMP-7 is a 28.8 kDa homodimeric glycoprotein consisting of two 116 amino acid subunits, which correspond to amino acid residues 316 to 431 of the full-length BMP-7 precursor.

AA Sequence:
MANVAENSSS DQRQACKKHE LYVSFRDLGW QDWIIAPEGY AAYYCEGECA FPLNSYMNAT NHAIVQTLVH FINPETVPKP CCAPTQLNAI SVLYFDDSSN VILKKYRNMV VRACGCH

Source:
CHO cells

Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.02-0.04 μg/ml.
 
Cross Reactivity:
Mouse