Quantum® Cell Expansion System

The Quantum system brings reproducibility and scalability to help companies get products from the lab to the market faster. By minimizing the need for hands-on attention, the system automates cell culture in a functionally closed environment.

At the core of this system is an advanced bioreactor with thousands of hollow fibers. The bioreactor provides an expansive surface area for cells to attach to in a compact space. Throughout each automated step of the culture process, from loading the cells through harvest, the functionally closed environment remains intact. Media and waste pass through porous membranes while the gas transfer module regulates gas concentration.

The Quantum system transforms open, labor-intensive manual tasks into a closed, automated and reproducible process.

The system cultures cells with four primary phases:
System is primed as the nutrients, metabolites and
gases diffuse across the fibers in the bioreactor

Cells are loaded into the bioreactor with approximately
2.1m² of surface area

Media exchange begins with the continuous control of
temperature, cell feeding and waste removal

Cells are harvested with the touch of a button in as little
as 20 minutes

 

Although the Quantum system automates each of these phases, lab personnel are still given a high-degree of customization. Throughout these phases, key process parameters can be monitored and adjusted to optimize the cell culture.

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QUANTUM DEVICE
Provides incubation, as well as media and gas exchange, in a functionally closed system

CELL EXPANSION SET
Includes a hollow-fiber bioreactor, gas transfer module, and waste and harvest bags

GRAPHICAL USER INTERFACE
Touch-screen enables pre-defined and user-defined tasks

Labor-intensive manual process	Automated, customizable process
Possibility of variation between lab personnel and each culture	Reproducible process and a high degree of scalability
Numerous open steps throughout the process	Functionally closed system from cell loading through harvest
Temperature fluctuations as flasks are moved in and out of the incubator	Continuous control of temperature
Manual pipette process to feed cells and remove waste	Automated and customizable control of cell feeding and waste removal
Cell harvest spans hours/days*	Cells harvested in as little as 20 minutes
Variable*	2.1 m2 (6.9 ft2) of surface area
Good Manufacturing Practice-grade clean room, hood, incubator and storage for flasks	.3 m2 (1 ft2) footprint

*Dependent on the number and capacity of flasks

For an in-depth analysis of your cell culture process: