ApplicationsE, WB, IHC, IP
Species reactivityH, M, B, P, Sh
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Data and Images
CD31 staining in mouse melanoma: Paraffin-embedded mouse melanoma cells are stained with CD31 Antibody (Cat. No. 250590) used at 1:200 dilution.
CD31 (PECAM1) is a member of the immunoglobulin (Ig) superfamily that is expressed on the surface of circulating platelets, monocytes, neutrophils, and particular T-cell subsets. CD31 is also a major constituent of the endothelial cell intercellular junction, where up to an estimated 1 million molecules are concentrated. Because of this cellular expression pattern, CD31 is implicated in several functions, including transendothelial migration of leukocytes, angiogenesis, and integrin activation. Ig superfamily members are known to mediate cell adhesion, or antigen recognition, e.g. immunoglobulins, T-cell receptors, and MHC molecules. In addition, a subgroup comprising 30 members characterized by the presence of one or more immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within their cytoplasmic domain has also been recognized. CD31, which has 6 ITIMs within its cytoplasmic domain, is a member of this subfamily.
Ma J et al. 2011. Tissue Engineering Part A. 18(1-2):103-116
Feng X., et al. 2009. J. Am. Soc. Nephrol. 20: 2138-2146.
Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; CPIIA'; CD31 antigen; PECAM1
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PECAM1.
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
|Cell Adhesion Molecules, CAM Ligands, Cellular Antigens, Enzymes, Glycan Binding Proteins, Immune System, Signaling Molecules & Interaction|