Catalog Number

252252

Unit

0.1 mg

Price

$430.00

Isotype

Applications

Species reactivity

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4. Antibody was purified by Protein-G affinity chromatography.

Description

CD31 (PECAM1) is a member of the immunoglobulin (Ig) superfamily that is expressed on the surface of circulating platelets, monocytes, neutrophils, and particular T-cell subsets. CD31 is also a major constituent of the endothelial cell intercellular junction, where up to an estimated 1 million molecules are concentrated. Because of this cellular expression pattern, CD31 is implicated in several functions, including transendothelial migration of leukocytes, angiogenesis, and integrin activation. Ig superfamily members are known to mediate cell adhesion, or antigen recognition, e.g. immunoglobulins, T-cell receptors, and MHC molecules. In addition, a subgroup comprising 30 members characterized by the presence of one or more immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within their cytoplasmic domain has also been recognized. CD31, which has 6 ITIMs within its cytoplasmic domain, is a member of this subfamily.

Recommended Products

250589 CD31 (N-term) Antibody
252266 CD31 (N-term) Antibody, FITC
 

Alternate Names

Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; CPIIA'; CD31 antigen; PECAM1

Accession No.

P16284
 

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CD31.

Application Notes

E: 1:500-1:1,000

WB: 1:200-1:500;

HC: 1:200-1:500

Storage

Store at -20°C. Product is guaranteed 6 months from the date of shipment.