Catalog Number

251014

Unit

2 ml

Price

$275.00

Isotype

Applications

Species reactivity

Format

Each vial contains 2 ml IgG (100 tests) in PBS pH7.4, 0.1% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Description

The CD29 (HI29a) antibody recognizes the 130-kDa transmembrane glycoprotein integrin β1 subunit which is the common β1 chain of the very late antigen (VLA) forming a non-covalent heterodimeric complex with several integrins α subunits that are receptors for extracellular matrix proteins such as collagen, fibronectin and osteopontin. CD29 has a broad tissue distribution including lymphocytes, monocytes, platelets, fibroblasts, and endothelial cells, whereas it is weakly expressed in granulocytes and absent in erythrocytes. CD29 is an important adhesion molecule involved in cell-cell and cell-extracellular matrix interactions. CD29 plays a critical role in the functional activity of lymphocytes by influencing cellular migration patterns as well as by transducing intracellular signals that influence lymphocyte function.

Recommended Products

250958 CD29 (HI29a) Antibody
251070 CD29 (HI29a) Antibody, PE
 

Alternate Names

Integrin beta-1; Fibronectin receptor subunit beta; Integrin VLA-4 subunit beta; CD29 antigen; ITGB1; FNRB; MDF2; MSK12

Accession No.

P05556
 

Clonality

HI29a

Application Notes

FACS with whole blood: 100 μl blood + 20 μl antibody; FACS with cells: 10E6 cells + 20 μl antibody.

Storage

Store at 4°C. Product is guaranteed 6 months from the date of shipment.