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乐博现货供应美国ProSci凋亡相关--Caspase-9 (IN1)antibody
乐博现货供应美国ProSci凋亡相关--Caspase-9 (IN1)antibody
  • 乐博现货供应美国ProSci凋亡相关--Caspase-9 (IN1)antibody

乐博现货供应美国ProSci凋亡相关--Caspase-9 (IN1)antibody

产品报价:2950元

更新时间:2012/7/18 15:54:31

地:北京

牌:ProSci

号:2071

厂商性质: 生产型,贸易型,服务型,

公司名称: 北京乐博生物科技有限公司

产品关键词:

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抗体信息如下:

Primary Antibodies

Caspase-9 Antibody

Background

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3 (1-3). Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation (3). Caspase-9 is also activated by granzyme B and CPP32 (1,2). Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (3). Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFα, TRAIL, anti-CD-95, FADD, and TRADD (4). Caspase-9 is expressed in a variety of human tissues (1,2).

 

Additional Names

Caspase-9 (IN1), Mch6/ Apaf-3, Casp-9

Caspase-9 Antibody

Description

Left: Western blot analysis of caspase-9 in HeLa whole cell lysate with caspase-9 antibody at 1:1000 dilution.

Source

Caspase-9 antibody was raised against a peptide corresponding to amino acids 41 to 56 of human caspase-9 .

Purification

Affinity chromatography purified via peptide column

Clonality / Clone

This is a polyclonal antibody.

Host

Caspase-9 antibody was raised in rabbit.

Please use anti-rabbit secondary antibodies.

Immunogen

Human Caspase-9 (Intermediate Domain 1) Peptide (Cat. No. 2071P)

Application

Caspase-9 antibody can be used for detection of caspase-9 by Western blot at 1:1000 to 1:2000 dilution. A 46 kDa band should be detected. It has no cross response to other members in caspase family.

Tested Application

E, WB

Buffer

Antibody is supplied in PBS containing 0.02% sodium azide.

Blocking Peptide

Cat. No. 2071P - Caspase-9 Peptide

Storage

Caspase-9 antibody can be stored at 4?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Positive Control

  1. Cat. No. 1201 - HeLa Cell Lysate

Species Reactivity

H, M, R

Protein GI Number

28558771

Protein Accession Number

P55211

Short Description

(IN1) A new caspase

This product belongs to the following categories:

  • Antibodies
  • Polyclonal Antibodies
  • Apoptosis Antibodies
  • Cancer Antibodies

Related Products

  • Caspase-9 Peptide
    (Catalog No. 2071P).
  • HeLa Cell Slide
    (Catalog No. 17-001).
  • HeLa Lysate
    (Catalog No. 1201).

References

  1. Duan H, Orth K, Chinnaiyan AM, Poirier GG, Froelich CJ, He WW, Dixit VM. ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem 1996;271:16720-4
  2. Srinivasula SM, Fernandes-Alnemri T, Zangrilli J, Robertson N, Armstrong RC, Wang L, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES. The Ced-3/interleukin 1β converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2α are substrates for the apoptotic mediator CPP32. J Biol Chem 1996;271:27099-106
  3. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997;91:479-89
  4. Pan G, O'Rourke K, Dixit VM. Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex. J Biol Chem 1998;273:5841-5 (RD1299)


 

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