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S5001 CP-690550 : JAK3 Inhibitor现货
S5001 CP-690550 : JAK3 Inhibitor现货
  • S5001 CP-690550 : JAK3 Inhibitor现货

S5001 CP-690550 : JAK3 Inhibitor现货

产品报价:询价

更新时间:2012/7/19 9:44:07

地:美国

牌:Selleck

号:S5001

厂商性质: 生产型,贸易型,服务型,

公司名称: 北京乐博生物科技有限公司

产品关键词:

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Biological Activity:
The only Janus Kinase 3 (JAK3) inhibitor currently in clinical trials; an immunosuppressive agent exhibiting potent effects in preclinical transplantation and arthritis models; clinically safe and effective in preventing transplant rejection and improving symptoms of rheumatoid arthritis and psoriasis. CP-690550 treatment of murine factor-dependent cell Patersen-erythropoietin receptor (FDCP-EpoR) cells harboring human wild-type or V617F JAK2 resulted in inhibition of cell proliferation with a IC50 of 2.1µM and 0.25 µM, respectively. Furthermore, CP-690550 treatment of ex-vivo-expanded erythroid progenitors from JAK2(V617F)-positive PV patients resulted in specific, antiproliferative (IC50 = 0.2µM) and pro-apoptotic activity. In contrast, expanded progenitors from healthy controls were less sensitive to CP-690550 in proliferation (IC50 > 1.0 µM), and apoptosis assays.
 
Technical Data:
M.Wt:  312.38
Formula:  C16H20N6O
Solubility:  Soluble in DMSO at 10 mM, –20°C
Purity:  >99%, Optical purity also>99%
Storage:  -20C 2 years
CAS No:  477600-75-2 
 
 

 

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