PHA-680632( Aurora抑制剂)现货
产品报价:6214元
更新时间:2012/7/19 9:36:48
产地:北京
品牌:selleck chem
型号:S1454
厂商性质: 生产型,贸易型,服务型,
公司名称: 北京乐博生物科技有限公司
刘小姐 : (13621283223) (4006130504)
(联系我时,请说明是在来宝网上看到的,谢谢!)产品报价:6214元
更新时间:2012/7/19 9:36:48
产地:北京
品牌:selleck chem
型号:S1454
厂商性质: 生产型,贸易型,服务型,
公司名称: 北京乐博生物科技有限公司
刘小姐 : (13621283223) (4006130504)
(联系我时,请说明是在来宝网上看到的,谢谢!)该产品另有其他规格及报价,欢迎来电垂询。
Technical Data:
M.Wt: 501.62
Formula: C28H35N7O2
Solubility: DMSO
Purity: >99%
Storage: at -20℃ 2 years
CAS No.: 398493-79-3
Biological Activity of PHA-680632:
PHA-680632 is the first representative of a new class of Aurora inhibitors (Aurora A/B/C IC50 at 27, 135 and 120 nM, respectively). This agent has a high potential for further development as an anticancer therapeutic.
PHA-680632 is active on a wide range of cancer cell lines and shows significant tumor growth inhibition in different animal tumor models at well-tolerated doses. The IC50 of PHA-680632 for cell anti-proliferation ranged from 0.11 µM to 5.6 µM. [1]
References on PHA-680632:
[1] Soncini C et al. Clin Cancer Res. 2006 Jul 1;12(13):4080-9