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商品编号:52627
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Leupeptin hemisulfate(亮肽素)

价    格:询价

产    地:德国更新时间:2019/7/15 13:41:34

品    牌:AppliChem型    号:A2183

状    态:正常点击量:1370

18210960361
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北京西美杰科技有限公司

联 系 人:方丽初

电     话:010-88597838

传     真:010-88595011

等     级: (第 12年)

性     质:生产型,贸易型,服务型,

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Leupeptin hemisulfate

A2183

Order No. Quantity
A2183,0010 10 mg
A2183,0025 25 mg
A2183,0100 100 mg


产品参数

Synonym Ac-Leu-Leu-argininal 
Formula C20H38N6O4 · ½H2SO4 
M 475.60 g/mol 
CAS-No. 103476-89-7 
HS-No. 29419000 
Storage -20°C 
LGK 10 - 13 
R 20/22 
S 28.1 
Hazard-Symbol harmful 
Specification  
Assay (HPLC) min. 96.5 % 
Solubility (1 %; H2O) clear 


产品介绍

(1)  Umezawa, H. (1976) Methods Enzymol. 45 (Part B), 678-695
Structures and activities of protease inhibitors of microbial origin.
  (2)  Brass, L.F. & Shattil, S.J. (1988) J. Biol. Chem. 263, 5210-5216
Inhibition of Thrombin-induced platelet activation by Leupeptin.

Hinweis

Leupeptin is a peptide antibiotic, isolated from several Streptomyces species. It is a reversible inhibitor of serine and cysteine proteases (e. g. plasmin, trypsin, papain, cathepsin B (1), thrombin (2), calcium-dependent protease calpain (2)). The halfmaximal inhibitory concentration (ID50) depends on the protease and ranges from 0.5 to 10 μg/ml. The working concentration is 10 - 100 μM (corresponds to 5 - 50 μg/ml), but as a starting concentration 2 μM (1 μg/ml) might be sufficient.
Stability: Leupeptin ist readily water-soluble. Aqueous stock solutions are set up with a concentration of 1 mg/ml. Leupeptin is stable in solutions at +4°C for approx. one week and at -20°C up to 6 months.



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