布莱恩·科比尔卡 Brian K. Kobilka

布莱恩·科比尔卡 Brian K. Kobilka 

布莱恩·科比尔卡（英语：Brian Kobilka，？－），美国斯坦福大学医学院的教授在分子和细胞生理学和医学部博士。他也是ConfometRx，一家专注于G-蛋白偶联受体的生物技术公司的共同创办人。在2011年他成为美国国家科学院院士。2012年获诺贝尔化学奖。
2012年诺贝尔化学奖罗伯特J. 勒夫科维兹(Robert J. Lefkowitz)和布莱恩·科比尔卡(Brian K. Kobilka)

 

Brian K. Kobilka教授现任斯坦福大学医学院分子与细胞生理与医学系教授，也是Confometrx生物技术公司的奠基人之一，2011年当选美国国家科科学院院士。

Kobilka教授以GPCR（G蛋白偶联受体）结构生物学研究著称，曾在2007年与另外一位科学家Raymond C. Stevens，利用T4溶菌酶融合蛋白方法解析了第一个非视紫红质GPCR晶体结构：人β2肾上腺素受体，这篇发表在Sciene上的文章被引上千次，后来他还独立地通过抗体片段介导法解析了人β2肾上腺素受体的结构。

Kobilka教授在GPCR结构生物学方面的重要贡献曾入选2007年Science十大科学突破成果，除此之外，他还荣获过2004年的Javit神经科学探索奖。

今年Kobilka教授研究组又接连在结构生物学领域获得重要突破，他们解析了结合激动剂的处于活性状态的人β2肾上腺素受体的结构（Nature，2011，被引56次）。随后又解析Gαβγ-β2肾上腺素受体复合物的结构，从而能够完整解释GPCR如何被配体激活以及再激活下游G蛋白从而传递信号的过程。这些突破性成果将对相关领域产生深远的影响。

Brian K. Kobilka, M.D., is a Nobel Prize winning professor in the departments of Molecular and Cellular Physiology and Medicine at Stanford University School of Medicinein the United States. He is also the co-founder of ConfometRx, a biotechnology company focusing on G-protein coupled receptors. He was named a member of the National Academy of Sciences in 2011.

Kobilka received a bachelor’s degree in biology and chemistry from the University of Minnesota, Duluth, earned his M.D., cum laude, from Yale University School of Medicine. Following residency in internal medicine at Washington University School of Medicine, Barnes Hospital, in St. Louis, Kobilka worked in research as an postdoctoral fellow underRobert Lefkowitz at Duke University where he started work on cloning the β₂-adrenergic receptor. Kobilka moved to Stanford in 1989.^[1] He was a Howard Hughes Medical Institute investigator from 1987-2003^[2] .

Kobilka is best known for his research on the structure and activity of G protein-coupled receptors (GPCRs); in particular, work from Kobilka's laboratory determined the molecular structure of the beta-2 adrenergic receptor.^[3][4][5][6] This work has been highly cited by other scientists because GPCRs are important targets for pharmaceutical therapeutics, but notoriously difficult to work with in X-ray crystallography.^[7]

Kobilka is the 1994 recipient of the American Society for Pharmacology and Experimental Therapeutics John J. Abel Award in Pharmacology.^[8] His GPCR structure work was named "runner-up" for the 2007 "Breakthrough of the Year" award from Science.^[9] The work was, in part, supported by Kobilka's 2004 Javits Neuroscience Investigator Award^[10] from the National Institute of Neurological Disorders and Stroke.^[11] He won the 2012 Nobel Prize in Chemistry for his work on G-Coupled receptors.