荷兰HyCult Biotechnology(HBT)  www.hbt.nl
荷兰HyCult Biotechnology(HBT)位于荷兰，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，还开发了相应的诊断ELISA试剂盒。近年来，HBT还开发了全世界独有的与心血管系统疾病相关的诊断试剂（如动脉粥样硬化蛋白C抗凝集途径、JAM-A内皮细胞途径）；磷脂氧化途径检测；TNF各亚型及各个受体全套产品；组织损伤标志物－FABP相关产品（如检测心脏、肝脏和小肠细胞损伤时出现的FABP）；细胞损伤检测－FABP；内毒素和其它微生物毒素的检测（内毒素抗体、内毒素阻断试剂、人BPI防御素、LBP和SLPI的抗体和ELISA试剂盒）。
 Hycult biotechnology b.v., also known as Hbt, produces recombinant proteins, monoclonal and polyclonal antibodies and ELISA kits for immunology and cell biology research.

Hbt products are manufactured and supplied according to ISO9001-2000 guidelines. The ISO certificate has been obtained for development, manufacturing and delivery of test kits, proteins, monoclonal and polyclonal antibodies in the field of microbial toxis, innate immunity, cell biology, toxicology and inflammatory mediators.

Main products are antibodies and assays for research of neutrophil proteins/antimicrobial peptides (Defensin, MPO, Calprotectin); early cell- and tissue damage (FABP); complement and collectins (MBL/MASP-2 and related proteins); vascular/oxidation damage (JAM, VAP-1, Nitrotyrosine); endotoxin & other microbial toxins, coagulation and Toll-like receptors.

Hbt Research

Hbt's aim in research is developing antibodies and assays that fulfill the need and demand of the research community. Products are being developed and commercialized in full cooperation with European, US, Japanese and Australian universities and research institutes.

Our program currently involves the development of reagents such as:

* Several Fatty Acid Binding Proteins (A-FABP and B-FABP) that happen to be excellent new and versatile markers for specific cell- and tissue damage detection
* Antibodies and assays for Collectin research (L-Ficolin, H-Ficolin, MASP-3, SP-A and SP-D).
* Neutrophil proteins / antimicrobial peptides (antibodies and assays for nGAL and beta-defensins)
* Assays for oxidative stress (MPO for various species such as rat, bovine and equine)
* Antibodies and assays for vascular research (ADAMTS13, ZO-1, JAM-A)
* Specific markers for intestinal diseases (sMAdCAM-1, I-LBP/IL-FABP)
* Neurological markers (brain alpha-dystroglycan, CCK1R, CCK2R)